Five actors have been cast in Season Four of the Emmy Award-winning series House, which premieres Tuesday, Sept. 25 (9:00-10:00 PM ET/PT) on FOX.

Olivia Wilde (The Black Donnellys, The O.C.), Kal Penn (24, The Namesake, Harold & Kumar Go to White Castle), Peter Jacobson (Starter Wife, Law & Order), Anne Dudek (Big Day) and Edi Gathegi (Lincoln Heights, Gone Baby Gone) play candidates for a fellowship opportunity with Dr. House. The actors have been cast for an undetermined number of episodes.

House stars Hugh Laurie as Dr. Gregory House, a brilliant diagnostician who thrives on the challenge of solving medical puzzles to save lives. In the Season Three finale, the set-in-his-ways House was confronted with a series of major changes to his team - neurologist Dr. Eric Foreman (Omar Epps) left Princeton Plainsboro because he didn't want to turn into House; House randomly fired old-money intensivist Dr. Robert Chase (Jesse Spencer), claiming he learned everything he's going to learn during the past three years, or nothing at all; and immunologist Dr. Allison Cameron (Jennifer Morrison) resigned, knowing House will be completely unaffected by her decision. But any effects of this "house-cleaning" on House, or the changes it may bring to House professionally or personally, remain to be seen...

During the recently completed 2006-07 season, House ranked as the No. 1 scripted series in Adults 18-49 and the overall No. 3 show in Adults 18-49 (behind only the Tuesday and Wednesday airings of American Idol). House ranks as FOX's No. 1 scripted program across the majority of key demos, including Adults 18-49, Adults 18-34 and Teens; ranks No. 1 in its Tuesday 9:00 PM time period among all key demos; and is the only scripted series to rank among primetime's Top 5 programs across Adults 18-49, Adults 18-34 and Teens.

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