Patricia Arquette and Kacey Barnfield have signed on to play the female leads in Glutton, which is being directed by Patricia Arquette's brother, David Arquette.

Abraham Benrubi will star in Glutton as a 1,200-pound bed-ridden man. Patricia Arquette will play his sister and caretaker, while Kacey Barnfield plays a blind neighbor who is his only friend.

David Arquette is directing this 3D horror tale from a script by Kenny Yakkel. Stan Spry, Cameron Larson, R. Scott Reid, Steve Ecclesine, and Lawreen E. Kayl will produce, with David Arquette also serving as executive producer.

Production is scheduled to start next month in Canada. This will be Patricia Arquette's first movie since the 2006 indie Fast Food Nation. Her TV show Medium ended its seven-season run in January.