The plot is set in 1950s Hollywood and centers on Eddie Mannix (George Clooney), a "fixer" who works with all of the major movie studios to keep the stars in line and to cover up any scandals. He is tasked with tracking down a major movie star who suddenly disappears in the middle of shooting a new movie. Patrick Fischler, David Krumholtz and Fisher Stevens are playing Hollywood screenwriters who are also Communists, while Clancy Brown plays an actor in the movie-within-a-movie, dubbed Hail Caesar.
Patrick Fischler recently wrapped production on a new untitled movie directed by Warren Beatty, while David Krumholtz can currently be seen in The Judge. Fisher Stevens is coming off a role in The Grand Budapest Hotel, while Clancy Brown recently starred in When the Game Stands Tall and he voices a role in The Spongebob Movie: Sponge Out of Water. He will also be seen in an upcoming episode of The Flash, and the video game adaptation Warcraft.