10 years ago, Harvard symbologist Robert Langdon transitioned from the pages of Dan Brown's hit novels to the big screen, with Tom Hanks portraying this iconic character in 2006's The Da Vinci Code. He returned three years later for the follow-up Angels & Demons, but it's been seven long years since we've seen Dr. Langdon on the big screen. That will change this fall with the upcoming Inferno, and today we have the second trailer with new footage.

This new trailer, which comes courtesy of Sony Pictures, finds the famous symbologist (again played by Tom Hanks) on a trail of clues tied to the great Dante himself. When Langdon wakes up in an Italian hospital with amnesia, he teams up with Sienna Brooks (Felicity Jones), a doctor he hopes will help him recover his memories. Together, they race across Europe and against the clock to stop a madman from unleashing a global virus that would wipe out half of the world's population.

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Academy Award winner Ron Howard returns to direct the latest bestseller in Dan Brown's billion-dollar Robert Langdon series, Inferno. The film's screenplay is written by David Koepp, based upon the novel by Dan Brown, with Brian Grazer and Ron Howard serving as the producers. Sony has set an October 28 release date for Inferno, putting it up against Paramount's Rings and an untitled horror film from Lionsgate.

Tom Hanks and Ron Howard's The Da Vinci Code and Angels & Demons have both earned over $1.2 billion worldwide to date. The supporting cast for Inferno is rounded out by Irrfan Khan as Harry Sims, a.k.a. The Provost, Omar Sy as Christoph Bruder and Sidse Babett Knudsen as Dr. Elizabeth Sinskey, the head of the World Health Organization. Ben Foster is playing the villain Bertrand Zobrist, a scientist trying to unleash a global plague that will solve the world's problem with overpopulation.

It isn't known if the filmmakers and Tom Hanks will team up to adapt Dan Brown's third Robert Langdon novel, The Lost Symbol, which was originally in development after Angels & Demons. Although the filmmakers decided to skip over that novel and make Inferno instead, based on the book of the same name that was published in 2013. Take a look at the new trailer for Inferno below, and stay tuned for more on this highly-anticipated adaptation.