According to Cinematical: Though the third installment in the franchise is still in production, folks behind the Resident Evil films are wasting no time casting the fourth flick. According to reports, Jensen Ackles (Supernatural, Dark Angel, Smallville) is in talks to play Leon Kennedy in Resident Evil: Afterlife (the fourth pic's current working title).

The third film in the series, Resident Evil: Extinction, stars Milla Jovovich, Oded Fehr, Mike Epps, Ali Larter, Chris Egan, Ashanti, Iain Glen, Sienna Guillory and will be release September 7, 2007.

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