According to Variety, Joe and Anthony Russo will direct You, Me and Dupree for Universal Pictures.
Owen Wilson will star in the laffer, about a best man who stays on as a houseguest with the newlywed couple, ultimately wearing out his welcome.
Dupree has been a high-priority project for U since the studio paid seven figures for Mike LeSieur's "Dupree" script earlier this year.
Wilson will also produce, while Aaron Kaplan and Sean Perrone will exec produce.
The studio is eyeing a start date later this year, possibly as early as August.