In a story from IGN, they had a chance to talk with John Hamburg and he offered up some good information about Little Fockers (which he is co-writing with Larry Stuckey).

"I'm currently writing Little Fockers, which is the third in the Meet the Parents franchise," he stated. "We're coming up with the story as we speak. Larry Stuckey wrote the original script, and I'm doing my version of it."

He went on to say, "We're catching up with these characters five years later and Pam and Greg have twins so they are dealing with that. And people are dealing with where they're at in their lives, and themes of death and divorce and all these real things that as we get older, we start to think about, but in a really comic way."

Hamburg went on to say that Owen Wilson will have a bigger role in Little Fockers.