In Thailand, a group of Christian aid workers recruit John Rambo to guide them up the Salween River to deliver medical supplies to the Karen tribe of neighboring Burma (aka Myanmar). When the missionaries fail to return, Rambo is persuaded to take a group of mercenaries back into the war-torn border region to find them. What follows is a descent into hell on earth.
The film was written by, directed by, produced by, and stars Stallone. John Rambo co-stars Julie Benz, Matthew Marsden, Graham McTavish, Rey Gallegos, Jake La Botz, Tim Kang and Paul Schulze.