Katherine Heigl is taking the place of Anne Hathaway in the new Judd Apatow comedy Knocked Up.

She'll star opposite Seth Rogan in the follow up to 2005's smash hit The 40 Year Old Virgin, which Judd is writing, directing and producing.

According to The Hollywood Reporter, Knocked Up centers on the unexpected pregnancy and other consequences of a man's one-night stand.

Hathaway left the picture due to creative differences. Knocked Up is set for a 2007 release.