IESB recently spoke to writer Kevin Williamson about his TV series Vampire Diaries but he also gave some details on Scream 4 as well.

I'm almost done with the first draft of Scream 4. I'm trying to get that together for Wes Craven. We've got to get going on that, during the hiatus. We have Neve Campbell, Courteney Cox and Dave Arquette. I was always holding out hope because the pitch was about those three characters. I didn't want to have to re-route the whole story. We don't have to do that. I can do it exactly the way I want wanted. The story is going to be told the way I originally conceived it.
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Williamson also revealed that he was hired to write a fifth film in the franchise as well. When asked whether Scream 4 will be in 3D, he answered with a definitive no.

No. I don't think Scream lends itself to a 3-D film. 3-D films are all about things being thrown at you. One of the things that Scream does is that it talks about those movies and sends them up, so actually putting in that device probably wouldn't work. I don't think it's an option. We're the movie that makes fun of it. I can imagine Stab being done in 3-D, but not Scream.

CLICK HERE for the site's full interview with Williamson.