In just one season, Dr. John Thackery (Clive Owen) has gone from a highly-regarded surgeon to a drug-addled mess when Cinemax's critically-acclaimed series The Knick returns for Season 2 with the premiere episode Ten Knots, debuting Friday, October 16 at 10 PM ET. While we wait for the season premiere to arrive in just a few short days, the network has released the first clip from this upcoming episode, which shows that Thackery has become quite unhinged. After a surprise visit by Dr. Everett Gallinger (Eric Johnson), Thackery becomes obsessed with the time.

Set in the year 1901, The Knick faces an upheaval, as Dr. John Thackery's absence (due to his hospitalization for cocaine addiction), a dearth of affluent patients, and financial missteps have led to the board's decision to shutter The Knickerbocker Hospital in favor of a new building uptown. In this world of corruption, invention and progress, everyone is searching for the new path that will help him or her survive. Whether it's a path toward justice, freedom, love or just plain survival, nothing comes easy.

As relocation plans proceed, the gifted but under-appreciated Dr. Algernon Edwards (Andre Holland) jockeys to become Thackery's successor as chief of surgery, while fellow doctors, nurses, nuns and administrators grapple with challenges at work and in their private lives. Also returning to star are Eve Hewson as Lucy Elkins, Juliet Rylance as Cornelia Robertson, Michael Angarano as Dr. Bertram "Bertie" Chickering, Jr., Cara Seymour as Sister Harriet, Chris Sullivan as Tom Cleary and Maya Kazan as Eleanor Gallinger. New cast members include Emily Kinney as Nurse Daisy Ryan, Andy Rannells as Frazier H. Wingo, the architect of the new Knickerbocker Hospital and Arielle Goldman as journalist Genevieve Everidge.

The Knick kicks off its ten-episode second season Friday, October 16 (10:00-11:00 p.m. ET/PT), exclusively on Cinemax, followed by other episodes debuting subsequent Fridays at the same time. Steven Soderbergh (Oscar winner for "Traffic"; Emmy winner for HBO's "Behind the Candelabra"; Emmy nominee for season one) directs the entire season of the show, which recently received an Emmy® in the category of Outstanding Production Design for a Narrative Period Program (One Hour or More). Gregory Jacobs (HBO's "Behind the Candelabra"; "Magic Mike XXL"), Steven Soderbergh, Michael Sugar ("The Fifth Estate," "Rendition") and Clive Owen executive produce. The writing team of Jack Amiel & Michael Begler ("Raising Helen," "Big Miracle") writes and executive produces. Michael Polaire (HBO's "Behind the Candelabra") produces. Steven Katz is the writer of season two episodes five and eight, and is co-executive producer.

The production designer is two-time Emmy-winner Howard Cummings (HBO's "Behind the Candelabra"); the costume designer is Emmy-winner Ellen Mirojnick (HBO's "Behind the Candelabra"); and the casting director is Emmy-winner Carmen Cuba (HBO's "Behind the Candelabra"). Composer Cliff Martinez ("Drive") is responsible for The Knick's critically acclaimed score. Emmy-winner Justin Raleigh ("American Horror Story: Freak Show," Emmy nominee for season one) designed the special effects makeup and prostheses for the series. Along with the new clip, Cinemax has released a new photo featuring Clive Owen's Dr. John Thackery, which you can check out below.

<strong><em>The Knick</em></strong> Season 2 Photo