Lauren Bacall passed away at the age of 89 today, after suffering a massive stroke in her Manhattan, New York home. The news was first reported by MSNBC reporter Thomas Roberts, which was confirmed by the estate of her late first husband, Humphrey Bogart, on their official Twitter feed.

Born Betty Joan Perske on September 16, 1924, Lauren Bacall became an overnight star with her role as Marie "Slim" Browning in 1944's To Have and Have Not, where she uttered the famous line, "You know how to whistle, don't you? You just put your lips together and blow." It was on that set that she met her first husband, Humphrey Bogart, whom she married in 1945. During their marriage, the couple starred in a number of classics together, such as The Big Sleep, Dark Passage, Key Largo, staying together until he passed away in 1957.

While she continued to work steadily during their marriage, it has long been believed that her outspoken political views hampered her career, after openly protesting the House Un-American Activities Committee and actively campaigning twice for Adlai Stevenson. She was under contract with Warner Bros. for several years, but she was suspended at least seven times.

She married actor Jason Robards in 1961, although the couple divorced in 1969. She continued to work throughout the 1960s and 1970s with memorable roles in Murder on the Orient Express and John Wayne's last feature, The Shootist. The actress also published her first memoir dubbed Now in 1978. She worked sporadically in the 1980s and 1990s in The Fan and Misery, receiving her first and only Oscar nomination for The Mirror Has Two Faces in 1996.

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Among her last film appearances are Lars von Trier's Dogville and Manderlay, Jonathan Glazer's Birth and 2012's The Forger alongside Josh Hutcherson and Hayden Panettiere. She also had a memorable cameo as herself in a 2006 episode of The Sopranos, and, earlier this year, she voiced the role of Evelyn, a friend of Peter Griffin's mother on Fox's Family Guy.

She is survived by her two children with Humphrey Bogart, Stephen and Leslie, and her son with Jason Robards, actor Sam Robards.