A Super Bowl XLV TV spot has been released for Limitless, which will hit theaters nationwide on March 18. Click on the video below to watch new footage from the Bradley Cooper/Robert De Niro thriller.

Bradley Cooper and Robert De Niro star in Limitless, a paranoia-fueled action thriller about an unpublished writer whose life is transformed by a top-secret "smart drug" that allows him to use 100% of his brain and become a perfect version of himself. His enhanced abilities soon attract shadowy forces that threaten his new life in this darkly comic and provocative film.

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Aspiring author Eddie Morra (Bradley Cooper) is suffering from chronic writer's block, but his life changes instantly when an old friend introduces him to NZT, a revolutionary new pharmaceutical that allows him to tap his full potential. With every synapse crackling, Eddie can recall everything he has ever read, seen or heard, learn any language in a day, comprehend complex equations and beguile anyone he meets-as long as he keeps taking the untested drug.

Soon Eddie takes Wall Street by storm, parlaying a small stake into millions. His accomplishments catch the eye of mega-mogul Carl Van Loon (Robert De Niro), who invites him to help broker the largest merger in corporate history. But they also bring Eddie to the attention of people willing to do anything to get their hands on his stash of NZT. With his life in jeopardy and the drug's brutal side effects grinding him down, Eddie dodges mysterious stalkers, a vicious gangster and an intense police investigation as he attempts to hang on to his dwindling supply long enough to outwit his enemies.