Mark Ruffalo will star and make his directorial debut with Sympathy for Delicious.

According to Variety, Ruffalo will star with James Franco and Chris Thornton.

Thornton, who wrote the script, plays "Delicious" Dean O'Dwyer, a paralyzed DJ struggling to survive in his wheelchair on the streets of L.A. He turns to faith-healing and mysteriously acquires the ability to cure the sick -- although not himself. Ruffalo plays a Jesuit priest who tries to help him come to terms with the limits of his gift, and Franco a rock singer in a band that exploits the suddenly famous healer.

Production begins this fall in Los Angeles.