Heroes star Milo Ventimiglia has signed on to star in the horror/thriller, Pathology for Lakeshore Entertainment.

Alyssa Milano, Lauren Lee Smith and Johnny Whitworth also have been cast in the movie, which is being directed by Marc Schoelermann. Written by Mark Neveldine and Brian Taylor (Crank), the story centers on a young intern (Ventimiglia) who is studying pathology at Philadelphia's University Hospital. The Hollywood Reporter adds he encounters an attractive but murderous group of colleagues who have devised a deadly game to see who among them can commit the perfect murder, while the others compete to determine the cause of death. Milano will play Ventimiglia's fiancee, while Smith and Whitworth are the med students.

Production on Pathology is scheduled to begin in May.