Are you ready to have the tears jerked right out of your face? Acclaimed director Catherine Hardwicke is back with a movie so emotional, you'll need to stock up on multiple boxes of Kleenex for both the theater, and the drive home. Presented by Lionsgate and Roadside Attractions, Miss You Already even teases one of the character's deaths in the title. How can this be anything but sad? Throw Toni Collette and Drew Barrymore in the mix, and you know buying a ticket to this drama means you'll be weeping for days. But it's not an entirely depressing affair. As evidenced in the latest trailer, there's a lot of laughs to be had in Miss You Already, too, as it celebrates the true meaning behind precious life.

Miss You Already is an honest and powerful story following two best friends, Milly (Toni Collette) and Jess (Drew Barrymore), as they navigate life's highs and lows. Inseparable since they were young girls, they can't remember a time they didn't share everything...Secrets, clothes, even boyfriends...But nothing prepares them for the day Milly is hit with life-altering news. A story for every modern woman, Miss You Already celebrates the bond of true friendship that ultimately can never be broken, even in life's toughest moments.

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Morwenna Banks makes her writing debut with Miss You Already, drawing on her own personal experiences. Best known as an actress, you may have seen Morwenna Banks in films such as Demons Never Die and Alien Autopsy. This latest project will definitely move her career in a completely new direction. Catherine Hardwicke is probably best known for directing 2008's Twilight, which kicked off that blockbuster vampire franchise in fashion. She made her directorial debut with the highly acclaimed drama Thirteen, which looked at the life of two teenage girls in the early 2000s. Her other noteworthy efforts include the edgy fairytale retelling Red Riding Hood and the skateboard biopic Lords of Dogtown.

Drew Barrymore hasn't appeared in a movie since 2014's Blended, where she re-teamed with Adam Sandler for a third time. The actress has been much more selective about the projects she accepts, with Miss You Already very near and dear to her heart. On the other hand, Toni Collette has appeared in seven various movie and TV projects all throughout 2014, and will next be seen in the holiday horror comedy Krampus. The pair are joined on screen by Paddy Considine, Dominic Cooper and Jacqueline Bisset.

Miss You Already is an official TIFF selection in the World Premiere Category. The film enters a crowded awards season, opening in theaters across the country in early November, making it an early holiday favorite. Will it have enough staying power and drama wattage to run the course? Judging from the trailer, it's possible that Drew Barrymore could garner her first ever Best Actress nomination from the Academy. She'll have stiff competition this year, including from her own co-star Toni Collette. She was nominated for Best Supporting Actress once before, in 2000 for role in Unbreakable. What do you think? Will we be seeing this one at next year's Oscars?