Paramount's Mission: Impossible Rogue Nation took the box office by storm this weekend, taking in an estimated $56 million for an easy win over New Line's comedy remake Vacation. Mission: Impossible Rogue Nation took in an impressive $14,156 per-screen average from 3,956 theaters this weekend, propelling it to victory over Vacation, which took in just $14.8 million in its first weekend in theaters. The opening weekend tally is the second highest for the action-packed franchise, behind Mission: Impossible 2's $57.8 million opening weekend back in 2000.

The opening weekend take is also the third-highest opening weekend for star Tom Cruise, behind War of the Worlds ($64.9 million) and Mission: Impossible 2. Over 85% of the audience were over the age of 25, setting up an interesting showdown next weekend with 20th Century Fox's superhero movie, Fantastic Four, which is tracking very well with males under the age of 25. Mission: Impossible Rogue Nation was released in 369 IMAX theaters this weekend, taking in $8.4 million. That tally is the third best for a July IMAX domestic opening behind The Dark Knight Rises' $19 million and Harry Potter and the Deathly Hallows - Part 2's $15.2 million.

Vacation pulled in $14.8 million from 3,448 theaters, for a $4,354 per-screen average. The comedy movie wasn't nearly as well-received as Mission: Impossible Rogue Nation (93% "Fresh" rating on Rotten Tomatoes), with just 23% of the nation's critics giving it a favorable rating. Ed Helms stars as a grown-up Rusty Griswold, who takes his wife (Christina Applegate) and their children (Skyler Gisondo, Steele Stebbins) on their first ever road trip to Walley World. Chris Hemsworth, Leslie Mann and Charlie Day co-star alongside Chevy Chase and Beverly D'Angelo, who reprise their roles as Clark and Ellen Griswold from the original comedy.

Related: Will Godzilla Stomp Rocketman & Aladdin at This Weekend's Box Office?

Rounding out the top 5 is Ant-Man ($12.6 million, $132.1 million overall domestic), Minions ($12.2 million, $287.3 million overall domestic) and (Pixels ($10.4 million, $45.6 million overall domestic). Minions should have no trouble cracking $300 million domestic this week, making it the fifth movie to do so all year, following Jurassic World ($631.5 million), Avengers: Age of Ultron ($457 million), Furious 7 ($351 million) and Inside Out($329.5 million). The bottom half of the top 10 includes Trainwreck $9.7 million, $79.7 million domestic), Southpaw ($7.5 million, $31.5 million domestic), Paper Towns ($4.6 million, $23.8 million domestic), Inside Out ($4.5 million, $329.5 million domestic) and Jurassic World ($3.8 million, $631.5 million domestic). Indies The End of the Tour ($126,000 from four theaters, $31,500 per-screen average) and A Lego Brickumentary ($42,000 from 93 theaters, $452 per-screen average) also opened this weekend to very different results.

Next weekend features four new movies debuting in wide release, along with several notable indies debuting in limited release. 20th Century Fox's Fantastic Four hits theaters next Friday, August 7, along with STX Entertainment's thriller The Gift, TriStar's drama Ricki and the Flash and Lionsgate's animated comedy Shaun the Sheep. Check back on Friday for our predictions, and again on Sunday for the box office estimates. Until then, check out this weekend's top 10 below.

WEEKEND BOX OFFICE:

1Mission: Impossible Rogue Nation
2Vacation
3Ant-Man
4Minions
5Pixels
6Trainwreck
7Southpaw
8Paper Towns
9Inside Out
10Jurassic World