Manny, Diego, and Sid are set adrift on an iceberg in this animated sequel from 20th Century Fox and Blue Sky Studios.
The Amazing Spider-Man drops to second place with $35 million, while Ted is in third place with $22.1 million.
Or will The Amazing Spider-Man fend off this animated sequel for a second straight win at the box office?
Take a look as fans all over the world get caught up in this new dance craze from 20th Century Fox's upcoming animated sequel.
Manny, Sid, and Diego go sailing through some treacherous waters in this scene from 20th Century Fox's animated sequel.
Ray Romano, Denis Leary, and John Leguizamo are back as Manny, Diego, and Sid in 20th Century Fox's upcoming animated sequel.
This 60-second commercial features Manny, Diego, and Sid as they embark upon another adventure after their continent is set adrift.
The U.K. pop group will contribute their new single 'Chasing the Sun' to the soundtrack for this 20th Century Fox animated sequel.
Manny, Diego, and Sid are set adrift on melting glaciers in 20th Century Fox's animated summer sequel.
Manny, Diego, Sid, and Scrat are back in this new animated adventure from 20th Century Fox.
Ray Romano, John Leguizamo, and Denis Leary all return for this 20th Century Fox animated sequel.
Take a look at this upcoming animated sequel, as told through the silent-film style of the Best Picture Oscar nominee.
The tormented muscrat's quest to retrieve an elusive nut continues in this new short from 20th Century Fox.
Scart's skunk flag has grown angry in this latest look at the upcoming 20th Century Fox animated adventure.
Scrat is adrift in this fourth installment of the popular Ice Age franchise, in theaters July of 2012.
Joy Behar, Nicki Minaj, Nick Frost and J.B. Smoove join the 20th Century Fox Animation project.
Wanda Sykes, Keke Palmer, Aziz Ansari and hip hop star Drake also to voice the 20th Century Fox animated project.
The saber-toothed squirrel continues his chase after a cursed nut in this new animated adventure.
Scrat's Continental Divide will be attached to prints of Gulliver's Travels this weekend.