Jesse Eisenberg, Anne Hathaway, and Leslie Mann lend their voices to this animated comedy about a young macaw who discovers he is the last male of his species.
Bridesmaids debuts in second place with a solid $24.5 million while Priest opened in fourth place with $14.5 million.
Fast Five drops to second place with $32.5 million while Jumping the Broom debuts in third place with $13.7 million.
Meanwhile, Prom is a big bomb and so is Hoodwinked Too.David Ozanich
Tyler Perry in drag can't beat the tropical birds of Rio.David Ozanich
Tyler Perry's latest effort is predicted to pull in $30 million, but will it fend off Rio.David Ozanich
Hollywood's 2011 box office slump is over for now with combined $139 million take.David Ozanich
Or can Scream 4 manage to get enough horror fans in those seats to cause an upset this weekend?David Ozanich
Ice Age director Carlos Saldanha takes some animated birds from Minnesota to Rio in this Fox adventure.
Get your first glimpse at footage from Captain America, Terra Nova, Thor, Super 8, Transformers 3, Pirates 4 and more.
Anne Hathaway and Neil Patrick Harris star as two birds who travel from Minnesota to Brazil in search of another Macaw.
Viewers could win a trip to Rio de Janeiro for the world premiere of this 20th Century Fox animated adventure.
Anne Hathaway and Neil Patrick Harris lend their voices to this 3D animated movie about a Minnesota bird who travels to Brazil.
Fox has now slotted the animated Rio for an April 15 release, while the drama Water for Elephants will bow on April 22.
The third poster has also arrived for Fox's 3D animated adventure about a Minnesota bird who seeks out a warmer climate.
Take a look at this new animated film from the creators of Ice Age