Wrath of the Titans takes second place with $34.5 million, while Mirror Mirror finishes in third place with $19 million.
Or will new releases Wrath of the Titans and Mirror Mirror pull off an upset victory?
The Lionsgate adaptation has the third best opening weekend in box office history behind Harry Potter and the Deathly Hallows - Part 2 and The Dark Knight.
The film opens Thursday at midnight with $19.7 million and should pull in an impressive $140 million before Monday.
Or will it fall short of Harry Potter and the Deathly Hallows - Part 2's $169.1 three-day box office record?
Lionsgate rolled out its Suzanne Collins adaptation in over 2,500 theaters last night, ahead of its wide release today.
EXCLUSIVE: The Hunger Games Cast Interviews with Jennifer Lawrence, Liam Hemsworth and Josh Hutcherson
Donald Sutherland, Elizabeth Banks, Woody Harrelson, and Lenny Kravitz also take us into the thrilling world of this anticipated thriller.
The odds are ever in your favor to win a pin and a number of different posters from the adaptation starring Jennifer Lawrence.
Liam Hemsworth offers some final advice to Jennifer Lawrence in this scene from Lionsgate's adaptation of the Suzanne Collins novel
The wait is almost over for Lionsgate's highly-anticipated movie event, hitting theaters March 23.
Donald Sutherland and Wes Bentley are featured in this latest look at the March 23rd release.
Jennifer Lawrence readies her bow and arrow in this new one-sheet for the upcoming Lionsgate adaptation.
Josh Hutcherson is put on display as Peeta Mellark in this scene from director Gary Ross' upcoming adaptation.
Jennifer Lawrence, Josh Hutcherson, Liam Hemsworth, Elizabeth Banks, and Woody Harrelson discuss their involvement in this adaptation.
Gary Ross directs this highly-anticipated Suzanne Collins adaptation starring Jennifer Lawrence and Josh Hutcherson as Katniss and Peeta.
A preview of the first trailer will be available Tuesday, March 20, with the full trailer debuting online Monday, March 26.
Jennifer Lawrence's Katniss Everdeen meets with her stylist in this scene from Gary Ross' highly-anticipated adaptation.
Jason Segel, Amy Adams, Kermit the Frog, and Miss Piggy star in director James Bobin's comedy, due on Blu-ray and DVD March 20.
Watch as Jennifer Lawrence tries to get noticed inside the training center before hitting the playing field.