The director is still in talks to come back for this Lionsgate sequel based on the popular Suzanne Collins novel.
Wrath of the Titans takes second place with $34.5 million, while Mirror Mirror finishes in third place with $19 million.
Or will new releases Wrath of the Titans and Mirror Mirror pull off an upset victory?
The Lionsgate adaptation has the third best opening weekend in box office history behind Harry Potter and the Deathly Hallows - Part 2 and The Dark Knight.
The film opens Thursday at midnight with $19.7 million and should pull in an impressive $140 million before Monday.B. Alan Orange
Or will it fall short of Harry Potter and the Deathly Hallows - Part 2's $169.1 three-day box office record?
Lionsgate rolled out its Suzanne Collins adaptation in over 2,500 theaters last night, ahead of its wide release today.
The Hunger Games Cast Interviews with Jennifer Lawrence, Liam Hemsworth and Josh Hutcherson [Exclusive]
Donald Sutherland, Elizabeth Banks, Woody Harrelson, and Lenny Kravitz also take us into the thrilling world of this anticipated thriller.B. Alan Orange
Gary Ross does a great job with this multi-layered adaptation, which doesn't drag one single bit and will have even die-hard fans of the book on the edge of their seats, even when they know exactly what will happen next.
The odds are ever in your favor to win a pin and a number of different posters from the adaptation starring Jennifer Lawrence.
Liam Hemsworth offers some final advice to Jennifer Lawrence in this scene from Lionsgate's adaptation of the Suzanne Collins novel
The wait is almost over for Lionsgate's highly-anticipated movie event, hitting theaters March 23.
Donald Sutherland and Wes Bentley are featured in this latest look at the March 23rd release.B. Alan Orange
Jennifer Lawrence readies her bow and arrow in this new one-sheet for the upcoming Lionsgate adaptation.
Josh Hutcherson is put on display as Peeta Mellark in this scene from director Gary Ross' upcoming adaptation.
Jennifer Lawrence, Josh Hutcherson, Liam Hemsworth, Elizabeth Banks, and Woody Harrelson discuss their involvement in this adaptation.
Gary Ross directs this highly-anticipated Suzanne Collins adaptation starring Jennifer Lawrence and Josh Hutcherson as Katniss and Peeta.
A preview of the first trailer will be available Tuesday, March 20, with the full trailer debuting online Monday, March 26.