Reese Witherspoon is caught between spies Chris Pine and Tom Hardy in director McG's action-comedy.
Ghost Rider Spirit of Vengeance finishes in third place with $22 million, while This Means War takes fifth place with $17.5 million.
Summit has also set an October 26, 2012 release for I, Alex Cross, while Fox has pushed This Means War to February 17.
Reese Witherspoon comes between super spies Tom Hardy and Chris Pine in this McG directed action thriller, in theaters this Valentine's Day.
Fox agreed to cut Chelsea Handler's sex jokes after the MPAA upheld the action-comedy's R rating yesterday.
20th Century Fox was hoping for a PG-13 rating in this action comedy starring Reese Witherspoon, Chris Pine, and Tom Hardy.
Reese Witherspoon stars as a woman caught between two dueling spies in this action-comedy.
The three day release date change comes after a positive test screening and strong word of mouth for this action comedy.
McG directs this action comedy about two highly-trained spies who fall for the same woman.
Reese Witherspoon, Tom Hardy, and Chris Pine star in McG's action-comedy about two spies who fall for the same woman.
Two new photos have also emerged from McG's action-comedy starring Reese Witherspoon, Tom Hardy, and Chris Pine.
Two posters have also been released for director McG's action comedy starring Reese Witherspoon and Tom Hardy.
The actress describes director Seth MacFarlane's unique role as director and voice actor in Ted, as well as her roles in This Means War and the Spider-Man video game.
Reese Witherspoon, Chris Pine and Tom Hardy star in the McG-directed action comedy.
Jeffery Dean Morgan stars in Hany Abu-Assad's thriller as a courier with a penchant for dangerous assignments.
The comedian will play best friend to Reese Witherspoon in this action comedy about two CIA agents after the same woman.
Chris Pine also stars in the McG-directed romantic comedy.
The Inception star has closed a deal for the long-delayed McG film.
The actor could battle Chris Pine for the love of Reese Witherspoon.
He would star opposite Reese Witherspoon in the buddy comedy.