Or can new releases Mama, The Last Stand and Broken City unseat the Oscar-nominated drama?
A Haunted House takes second place with $18.8 million, while Gangster Squad finishes in third place with $16.6 million.
Or could Gangster Squad and the horror spoof A Haunted House take home the box office crown?
Jessica Chastain, Jason Clarke, Jennifer Ehle and Kyle Chandler are on hand to discuss director Kathryn Bigelow's riveting account of the search for Osama Bin Laden.
Director Kathryn Bigelow, screenwriter Mark Boal, and star Jessica Chastain discuss this true story drama about the manhunt for Osama bin Laden.
Golden Globe nominee Jessica Chastain stars in this military thriller, based on the events that lead up to Osama bin Laden's death.
Kathryn Bigleow directs this military thriller based on the Seal Team Six mission to hunt down the infamous terrorist.
Jessica Chastain tries to convince Kyle Chandler to go after Osama bin Laden in this scene from director Kathryn Bigelow's thriller.
Check out the latest from Kathryn Bigelow's Osama Bin Laden assassination thriller.
Director Kathryn Bigelow chronicles the hunt for terrorist Osama bin Laden in this drama starring Joel Edgerton and Jessica Chastain.
We also have a first look photo of James Gandolfini as Leon Panetta, the head of the CIA in Kathryn Bigelow's military thriller.
The Hurt Locker director Kathryn Bigelow re-teams with writer Mark Boal for this thriller about the assassination of terrorist Osama bin Laden.
Get your first look at Kathryn Bigelow's military thriller about the Seal Team Six unit that killed Osama bin Laden.
The film follows the black ops SEAL team who successfully took down Osama Bin Laden.
The Super 8 actor joins this Mark Boal-scripted drama about an elite military unit hunting down terrorist Osama bin Laden.
The Parks and Recreation star will take on a more serious role in this look at the Navy SEAL team that killed Bin Laden.
The Chicago Code star will portray a solider in an elite group tasked to hunt down Osama bin Laden.
The director is teaming up with The Hurt Locker writer Mark Boal for this project loosely based on the Seal Team Six's mission to kill Osama bin Laden.
The director will team up again with The Hurt Locker writer Mark Boal for this new drama about the Navy SEAL team responsible for Osama bin Laden's death.