Nikki Cox is set to star in CBS' comedy pilot Fugly; it revolves around three siblings, identical twin sisters (Cox, Marissa Jaret Winokur) and a brother, who buy one of the sisters (Cox) an extreme makeover and move to Hollywood to capitalize on her newfound good looks.

Eliza Dushku is set to star in Fox's one-hour dramedy pilot Nurses. The show is about the lives and loves of a team of nurses. The Hollywood Reporter says Dushku will play the lead, a young woman just out of nursing school who joins the hospital run by her father. Also cast in the pilot is Jaclyn DeSantis, who will play an experienced nurse going through a bitter divorce.

Amber Valletta will star in CBS' drama pilot Twilight, which centers on a PI (Alex O'Laughlin) who is a vampire; Valletta will play his timeless love, a vampire who made him immortal after biting him on their wedding night.

Joshua Malina and Nia Long have landed lead roles on ABC's untitled Jon Feldman drama pilot. The show centers on four high-powered CEOs and CEOs-to-be (Dylan McDermott, Michael Vartan, Christopher Titus, Malina) who are friends and members of the same golf club. Malina will play the CEO of a large pharmaceutical company who is sweet but insecure; Long will play Vartan's character "work wife."

Autumn Reeser and David Walton have joined CW's untitled Tom Wheeler pilot; it centers on a brilliant graduate student (Ryan Devlin) and his friends, who use their skills to solve crimes. Reeser will play the Devlin character's down-to-earth girlfriend, a paralegal and the daughter of an FBI agent.

Beverly D'Angelo has been added to CBS' drama pilot Skip Tracer, which centers on a skip tracer (Stephen Dorff), a guy who finds people who have tried to disappear; D'Angelo will play his mom, who is in prison for the murder of her husband.

According to Variety, Danielle Hoover has been added to the Fox 21 comedy Revenge as a nurse who recently returned from Iraq.

Meghan Markle will play Kelly Calhoun, wife of John 'Preacher' Calhoun (Keith Robinson), in the 20th Century Fox TV pilot The Apostles; Michael Rapaport is also close to signing onto the show.

Tony Gentile has signed on to CBS' comedy, Stumps.