Doctor Who star Matt Smith has signed on to star in the Screen Gems zombie thriller Patient Zero, alongside Game of Thrones actress Natalie Dormer.

The action-thriller takes place in the aftermath of a deadly pandemic where an enhanced strain of rabies turns humans into violent, zombie-like creatures. The plot centers on a man who is not only surprisingly immune to this disease, but has the ability to communicate with the dangerous species. He leads a quest to find Patient Zero, in hopes of finding a cure to save his infected wife and the rest of humanity.

Stefan Ruzowitzky (The Counterfeiters, Deadfall) is directing from a screenplay by Mike Le (W.M.D.), with Vincent Newman (We're the Millers, Paradise Lost) producing. No production schedule was given.

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Matt Smith, who left Doctor Who last year, will next be seen in Pride and Prejudice and Zombies, Terminator Genisys and Ryan Gosling's directorial debut, Lost River.