Fantastic Voyage is going to be shot in 3D, and it will employ the same technologies that Cameron and Jon Landau's Lightstorm made for Avatar. Cameron is also one of the producers on the sci-fi project.
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The story focuses on "a dying scientist whose only chance for survival rests with five colleagues who are miniaturized and injected into his bloodstream."
The original Fantastic Voyage was directed by Richard Fleischer. It starred Raquel Welch and Donald Pleasence.