The actor will star in and produce this adaptation of the book that delves deeper into the John F. Kennedy assassination.
The actor will star as HH Holmes, a 19th-Century serial killer who murdered anywhere between 27 and 200 people.
Rebecca Hall is up for the role, but the director wants to work shop the script with other actresses before moving ahead.
Amanda Seyfried's name was also mentioned for the film, which Baz Luhrmann is considering directing.
Scott is said to be in serious talks to direct Jordan Belfort's memoir.
Clint Eastwood will direct this upcoming film for Warner Brothers later in the fall.
The actor is in early talks for the biopic on FBI leader J. Edgar Hoover.