Reese Witherspoon has signed on to play a giant in a new animated battle movie Monsters vs. Aliens.

According to, the Oscar-winning actress will team up with Hugh Laurie, Seth Rogen and Kiefer Sutherland, among others, to voice quirky characters in Dreamworks' upcoming film.

Witherspoon's character, Susan Murphy, becomes a 50-foot monster, dubbed Ginormia, after she's hit by a meteor from outer space. She's then captured by the U.S. military and taken to a top-secret compound, where other 'monsters' are kept.

These include the insect-headed Dr. Cockroach (Laurie) and half-ape/half-fish Missing Link (Will Arnett). Sutherland will voice the aptly named General W.R. Monger. The monsters team up to attack invading aliens.