Resident Evil: Retribution is currently in production, working towards a September 14, 2012 release date. Actress Michelle Rodriguez, who played Rain Ocampo in the original Resident Evil, has signed on to reprise that role in Resident Evil: Retribution.

The production has already announced cast members from previous Resident Evil movies are returning, such as Sienna Guillory (Jill Valentine) and Colin Salmon (One). It is not clear how Rain Ocampo will fit into the story line of Resident Evil: Retribution. It has also been confirmed that Resident Evil: Afterlife's Shawn Roberts will have a cameo appearance as Albert Wesker.

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Paul W.S. Anderson is directing Resident Evil: Retribution from his own screenplay. A September 14, 2012 release date has already been set.