Ron Perlman has defined the character of Hellboy nearly as strongly as the character's creator, Mike Mignolla. He created the role for the first Hellboy movie, and is reprising the role in this summer's Hellboy II: The Golden Army, both of which were directed by Guillermo del Toro. He has also provided the voice of the character for several Hellboy animated features, including to Hellboy: Sword of Storms and Hellboy: Blood & Iron, as well as the upcoming Hellboy: The Phantom Claw. And now, according to SCI-FI Wire, he is now providing the voice for the character in Komani's Hellboy: The Science of Evil video game.

Perlman says that he involved himself in the game, in part, due to the involvement of del Toro and Mignola in the development of the character. "I do not play video games, so I am unfamiliar with the finished product of the Hellboy game," Perlman says. "I can only judge it on the level of what my experience acting the roles offered to me was like. And I thought the writing for the game was smart and well realized, with the extra added attraction of Guillermo's personal involvement in the project." Perlman adds "Anything that contributes to the general public's engagement and interest in as beloved a character as Hellboy is to me ... of major concern."

The game features a new story not directly tied to either film, which continues the adventures of Hellboy, Abe Sapien, Liz Sherman and the rest of the team from the Bureau for Paranormal Research and Defense.