Your favorite scientists and girl-next-door are back as The Big Bang Theory returns to CBS this fall for an all-new season of exasperatingly funny episodes. While at Comic-Con 2009, we caught up with the cast of this popular sitcom to find out what's in store for Leonard, Sheldon, and Penny this year. To watch our exclusive video interviews with Johnny Galecki, Simon Helberg and Kunal Nayyar, click below!

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The Big Bang Theory returns this fall on CBS.