What do you do after you've been diagnoses with cancer and survive? Well, if you're friends with Seth Rogen, you make a movie about it and cast him as your best friend. That's what writer Will Reiser did, casting Joseph Gordon-Levitt as himself, and getting Jonathan Levine, who made the great lost horror gem All the Boys Love Mandy Lane, to direct. Summit Entertainment has released the second trailer for 50/50, which you can check out below. Be careful, its been diagnosed with a case of the sillies, and its contagious!