Sigourney Weaver is reteaming with James Cameron for the sci-fi adventure, Avatar for 20th Century Fox; it's her first collaboration with the director since Aliens.

She'll take a supporting role alongside lead actors Sam Worthington and Zoe Saldana, says The Hollywood Reporter. Also joining the cast for the heavily anticipated film are Joel David Moore, CCH Pounder, Peter Mensah, Laz Alonso and Wes Studi. In the CGI-intensive film, which will be shot in 3-D, Weaver will play veteran explorer Grace, who serves as a mentor to Worthington's character Jake, a wounded former Marine who leads his indigenous race in an interplanetary battle for survival.

Avatar begins principal photography in April, with plans for a summer 2009 3-D release.