The original Spy Kids team up with a whole new crew in this latest adventure, on Blu-ray and DVD November 22nd.
Jessica Alba and Joel McHale star alongside former Spy Kids Alexa Vega and Daryl Sabara in Robert Rodriguez's children's adventure.
Spy Kids: All the Time in the World takes third place with $12 million while Fright Night takes sixth place with $7.9 million.
Or will Conan the Barbarian and Fright Night fight it out for that coveted number one spot at the box office?
Director Robert Rodriguez shows off some of the gadgets from his 3D adventure starring Jessica Alba and Joel McHale.
Jessica Alba and Joel McHale star in director Robert Rodriguez's latest installment of this covert children series.
8 specially selected scenes will unleash wild odors into the auditorium during Robert Rodriguez's groundbreaking sequel.
Jessica Alba and Joel McHale lead a family of spies in Robert Rodriguez's reboot of this popular kid-friendly franchise.
Jessica Alba and Joel McHale star in Robert Rodriguez's new kid-friendly 3D spy adventure.
Jessica Alba, Joel McHale and Jeremy Piven star in the Robert Rodriguez-directed fourth installment.
The British comedian will lend his voice to the robot spy dog Argonaut in Robert Rodriguez's children's adventure.
The actress tries to juggle parenting and spy work all at once in this new photo from the Robert Rodriguez sequel.
The return of original spies Daryl Sabara and Alexa Vega can also be seen on the set of Robert Rodriguez' upcoming sequel.
Production on Robert Rodriguez's anticipated sequel has begun in Austin, Texas.
The Community star will play a reporter married to Jessica Alba's reactivated spy in Robert Rodriguez's new 3D adventure.
Reteaming with Robert Rodriguez for the Dimension Films reboot.
The popular writer/director/producer talks about a possible prequel to his new film and some of his other upcoming projects.
The Robert Rodriguez sequel will begin filming in July.
The Robert Rodriguez film will be released on August 11, 2011.