Sylvester Stallone recently dropped some new information about his upcoming fifth installment of the John Rambo series Rambo V: A Savage Hunt to AICN, the first item being the new title. He also said that the film will indeed take place in the United States, but that it will be structured differently from the sequels we've seen in the past.
According to Stallone himself, Rambo V: A Savage Hunt will take place in the Pacific Northwest, in the general area where First Blood took place. Rambo will come in contact with a secret U.S. Military instillation that is conducting SAVAGERY experiments on soliders. Their plan is to create brilliant, instinctual killer soldiers that have no qualms about killing other men in combat. In Sly's conversation with AICN, he brought up the ancient Immortals, a group of children that were raised to kill since birth.
The story has the experiments working out for the military, until one of the killers becomes unstoppable and sets off on a rampage. John Rambo is brought in as part of a Black Ops Squad to capture and kill this "worse than Rambo" soldier. AICN also has an image of the 1-Sheet that Sly will be bringing to the Toronto Film Festival, which you can check out below: