Supermodel Alessandra Ambrosio has signed on to star in Teenage Mutant Ninja Turtles 2, playing herself, who is the new love interest for Will Arnett's Vern Fenwick. Both Alessandra Ambrosio and Will Arnett were spotted at a recent Los Angeles Clippers vs. New York Knicks game together, where they were shooting scenes for the sequel. It isn't known if production has fully begun yet, or if the production just took advantage of the game to shoot a few scenes for the sequel. Several Los Angeles Clippers players such as DeAndre Jordan, J.J. Redick, Matt Barnes, Austin Rivers, and Spencer Hawes also shot a scene for the sequel.

Teenage Mutant Ninja Turtles stars Alan Ritchson (Raphael), Noel Fisher (Michelangelo), Pete Ploszek (Leonardo) and Jeremy Howard (Donatello) are expected to return as the turtles, along with Megan Fox (April O'Neil) and William Fichtner (Eric Sacks). No story details have been released at this time for the sequel. Teenage Mutant Ninja Turtles 2 has already been given a June 3, 2016 release date.

Dave Green (Earth to Echo) is directing from a script by Teenage Mutant Ninja Turtles writers Josh Appelbaum and André Nemec. Michael Bay is producing through his Platinum Dunes company. Alessandra Ambrosio, best known as one of the Victoria's Secret Angels, had a minor role in 2006's Casino Royale, and she will next be seen in Daddy's Home alongside Mark Wahlberg and Will Ferrell. She has also appeared in episodes of Entourage and Gossip Girl.