According to Production Weekly, Sylvester Stallone is set to reprise his role of Vietnam vet John Rambo, in the third sequel in the Rambo: First Blood Part II franchise. Stallone will also produce and direct the film based on his own script titled, Rambo IV: In The Serpent's Eye. Production is tentatively slated for January in Thailand.

The next chapter finds Rambo recruited by a group of Christian human rights missionaries to protect them against pirates, during a humanitarian aid deliver to the persecuted Karen people of Burma. After some of the missionaries are taken prisoner by sadistic Burmese soldiers, Rambo gets a second impossible job: to assemble a team of mercenaries to rescue the surviving relief workers.

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