HBO has released the first trailer for the upcoming TV movie The Normal Heart, which is slated to debut Sunday, May 25 at 9 PM ET. Mark Ruffalo stars as activist Ned Weeks, who seeks answers from New York politicians as the AIDS epidemic grows in the early 1980s. Julia Roberts, Taylor Kitsch, Matthew Bomer and Alfred Molina round out an all-star cast for this drama directed by Ryan Murphy (Glee, American Horror Story), based on Larry Kramer's groundbreaking play of the same name.

Directed by Emmy winner Ryan Murphy (Eat, Pray, Love, Glee) and written by Academy Award nominee Larry Kramer (Women in Love), adapting his groundbreaking Tony Award-winning play of the same name, the drama tells the story of the onset of the HIV-AIDS crisis in New York City in the early 1980s, taking an unflinching look at the nation's sexual politics as gay activists and their allies in the medical community fight to expose the truth about the burgeoning epidemic to a city and nation in denial. The Normal Heart will debut exclusively on HBO in May.

Ruffalo portrays Ned Weeks, who witnesses first-hand a mysterious disease that has begun to claim the lives of many in his gay community and starts to seek answers. Matthew Bomer plays Felix Turner, a reporter who becomes Ned's lover. Taylor Kitsch plays Bruce Niles, a closeted investment banker who becomes a prominent AIDS activist. Jim Parsons plays gay activist Tommy Boatwright, reprising his role from the 2011 Broadway revival. Julia Roberts plays physician Dr. Emma Brookner, a survivor of childhood polio who treats several of the earliest victims of HIV-AIDS.

Alfred Molina plays Ned's older brother, Ben, who is a successful attorney. Joe Mantello plays Mickey Marcus, who is an instrumental member of the Gay Men's Health Crisis. Jonathan Groff plays Craig, Bruce's lover, an early victim of HIV-AIDS. Denis O'Hare portrays Hiram Keebler, Mayor Koch's gay aide. Stephen Spinella plays Sanford, one of Dr. Brookner's first patients. Corey Stoll portrays presidential senior advisor John Bower. Finn Wittrock plays Albert, a male model. B.D. Wong portrays Buzzy, a nurse who works with Dr. Brookner.