Uma Thurman is in negotiations to board Nima Nourizadeh's action comedy American Ultra. The project already has Jesse Eisenberg and Kristen Stewart attached to star.

The story follows Mike, a lazy stoner (Jesse Eisenberg), who lives a quiet life with his girlfriend (Kristen Stewart). One random night, the couples' lives change when something from Mike's past surfaces. He then finds himself in the middle of a government operation trying to take him out. Max Landis wrote the screenplay.

Uma Thurman will play a government agent, who started the secret program that is hunting the couple. The actress will next be seen as Mrs. H in Lars von Trier's drama Nymphomaniac Volume I.

Palmstar Media Capital's Kevin Scott Frakes will be producing alongside Raj Brinder Singh. Lionsgate will be distributing. Production is slated to begin in April.