It appears that Sony is indeed moving forward with a new Spider-Man film, but it appears that Tobey Maguire is no part of it. According to Latino Review, two names have been kicked around by producers Laura Ziskin and Grant Curtis to replace Maguire: Patrick Fugit and Michael Angarno.
No offers have been made to either actor as of yet, but those two appear to be at the top of the short list to portray Spidey. Oddly enough, the two actors have worked together in the same movie... as the same character. Fugit portrayed the teenage version of William Miller in Almost Famous while Angarno played the the younger version.
It isn't clear if the Spidey overhaul is extending to the rest of the cast, but we'll be sure to keep you posted on more developments in this new movie.