The story centers on Daniel Asa Rose (Will Ferrell), who travels to China with his awkward cousin (Zach Galifianakis) and his mail-order bride to secure an illegal kidney transplant that will save his life.
Richard Linklater is directing, although it isn't known if there is a screenwriter attached at this time, or if the filmmaker plans on adapting the book himself. Scott Aversano is producing the adaptation, which balances comedy with life and death stakes. The Focus Features bio page for the producer's film That Awkward Moment reveals Larry's Kidney will start shooting this spring, although it isn't known if production is under way or not. It also isn't known if the production will shoot in China, which is one of the fastest growing movie markets in the world.
Will Ferrell recently starred in the blockbuster The Lego Movie, and he will next be seen in Get Hard. Zach Galifianakis had a cameo in this spring's Muppets Most Wanted, and he will next be seen in Birdman.