Winona Ryder has agreed to star in the indie comedy, Sex and Death 101.

The film reunites Winona with director Daniel Waters, who wrote Heathers and made her a major star. She will play a feminist vigilante who becomes an urban folk hero; the story follows a man (Simon Baker) whose life is upended by a mysterious e-mail containing the 101 names of every woman he has had sex with and, eerily, every woman he will have sex with in the future. The Hollywood Reporter adds he is stopped in his tracks when he meets Ryder, a femme fatale who targets men guilty of sex crimes against women.

Sex and Death 101 is scheduled for a start for production this month; a 2007 date is set for the release.